Title of article
6-Deoxy-6-hydroxymethyl scyllo-inositol 1,2,4-trisphosphate: A potent agonist at the inositol 1,4,5-trisphosphate receptor
Author/Authors
Andrew M. Riley، نويسنده , , Christine T. Murphy، نويسنده , , Catherine J. Lindley، نويسنده , , John Westwick، نويسنده , , Barry V. L. Potter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2197
To page
2200
Abstract
The synthesis of racemic 6-deoxy-6-hydroxymethyl scyllo-inositol 1,2,4-trisphosphate is described. This compound is a highly potent agonist at the platelet -myo-inositol 1,4,5-trisphosphate receptor, and it binds to the rat cerebellar receptor with an affinity equal to that of the natural ligand. These results suggest that the 5″-hydroxymethyl group of adenophostin A may contribute to its unusual potency.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788323
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