Author/Authors :
Scott I Klein، نويسنده , , Jeffrey S Dener، نويسنده , , Bruce F Molino، نويسنده , , Charles A Gardner ، نويسنده , , Rose DʹAlisa، نويسنده , , Christopher T Dunwiddie، نويسنده , , Charles Kasiewski، نويسنده , , Robert J Leadley، نويسنده ,
Abstract :
A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-Pro dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective, than PPACK itself.
