Title of article
O-benzyl hydroxyproline as a bioisostere for Phe-Pro: Novel dipeptide thrombin inhibitors
Author/Authors
Scott I Klein، نويسنده , , Jeffrey S Dener، نويسنده , , Bruce F Molino، نويسنده , , Charles A Gardner ، نويسنده , , Rose DʹAlisa، نويسنده , , Christopher T Dunwiddie، نويسنده , , Charles Kasiewski، نويسنده , , Robert J Leadley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
2225
To page
2230
Abstract
A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-Pro dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective, than PPACK itself.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788329
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