Recognition in molecularly imprinted polymer α2-adrenoreceptor mimics

Molecularly imprinted polymers (MIPs) selective for the α2-adrenoreceptor antagonist yohimbine (1) have been prepared and studied as α2-adrenoreceptor mimics. Marked ligand stereoselectivity was demonstrated in radioligand binding and HPLC studies upon comparison to blank and corynanthine (2) MIPs. KD values in the nanomolar range have been shown for anti-1 MIP prepared in chloroform solutions upon rebinding in organic media.