Author/Authors :
Michael R. Wiley، نويسنده , , Nickolay Y. Chirgadze، نويسنده , , David K. Clawson، نويسنده , , Trelia J. Craft، نويسنده , , Donetta S. Gifford-Moore، نويسنده , , Noel D. Jones، نويسنده , , Jennifer L. Olkowski، نويسنده , , Leonard C. Weir، نويسنده , , Gerald F. Smith، نويسنده ,
Abstract :
The design, synthesis, and enzyme inhibitory profile of D-Phe-Pro-p-Amidinobenzylamine are presented. This compound has inhibitory activity equivalent to D-Phe-Pro-Arg-H, two orders of magnitude more potent than D-Phe-Pro-Agmatine. The results indicate that binding energy provided by the covalent bond of a transition-state analog can be replaced with noncovalent interactions.
