Title of article
Halogen substitution at the isoxazole ring enhances the activity of N-(isoxazolyl)sulfonamide endothelin antagonists
Author/Authors
Ming Fai Chan، نويسنده , , C. B. Raju ، نويسنده , , Adam Kois، نويسنده , , Rosario S. Castillo، نويسنده , , Erik J. Verner، نويسنده , , Chengde Wu، نويسنده , , Emily Hwang، نويسنده , , Ilya Okun، نويسنده , , Fiona Stavros، نويسنده , , V. N. Balaji، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
2393
To page
2398
Abstract
Replacement of the 4-methyl group in a series of N-(3,4-dimethylisoxazolyl)benzenesulfonamide endothelin antagonists with a bromine or chlorine atom resulted in a three- to ten-fold increase in the binding affinity for both the ETA and ETB receptors. This potentiation in activities was also observed for naphthalene and biphenylsulfonamide endothelin antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788363
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