Author/Authors :
Denis Danvy، نويسنده , , Thierry Monteil، نويسنده , , Jean-Christophe Plaquevent، نويسنده , , Lucette Duhamel، نويسنده , , Pierre Duhamel، نويسنده , , Claude Gros، نويسنده , , Nadine Noël، نويسنده , , Jean Charles Schwartz، نويسنده , , Jeanne-Marie Lecomte، نويسنده ,
Abstract :
The preferred conformation of thiorphan during the inhibitor-neprilysin docking process was investigated. A series of achiral inhibitors were tested. This study led to the design of a potent inhibitor, in which the ethylenic bond bears the aryl residue of P′1.
