Title of article
Synthesis and antibacterial activity of lipophilic carbapenems with anti-MRSA activity
Author/Authors
Jean Claude Arnould، نويسنده , , Ruth N Illingworth، نويسنده , , Wright W Nichols، نويسنده , , R. Geoffrey Wilson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
2449
To page
2454
Abstract
A series of sulphur-linked and carbon-linked lipophilic carbapenems has been prepared and evaluated for antibacterial activity in vitro and in vivo and for affinity for PBP2′ of Staphylococcus aureus. Potent activity in vitro against methicillin-resistant S. aureus and methicillin-resistant coagulase negative staphylococci was observed despite IC50 values for PBP2′ being higher than the MIC.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788374
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