Author/Authors :
Richard L. Jarvest، نويسنده , , Martin J. Parratt، نويسنده , , Christine M. Debouck، نويسنده , , Joselina G. Gorniak، نويسنده , , L. John Jennings، نويسنده , , Halina T. Serafinowska، نويسنده , , James E. Strickler، نويسنده ,
Abstract :
Benzoxazinones have been discovered which are mechanism based inhibitors of HSV-1 protease with micromolar IC50 values. Formation of a monoadduct consistent with the acyl-enzyme complex was detected by mass spectroscopy. A parallel array synthesis was developed to explore 2-heteroatom substituted SAR.
