Title of article
Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine
Author/Authors
John A. Brinkman، نويسنده , , Robert E. Damon، نويسنده , , Jay B. Fell، نويسنده , , Lawerence B. Perez، نويسنده , , Terence J. Scallen، نويسنده , , T. R. Vedamanda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2491
To page
2494
Abstract
Squalene synthase catalyzes the committed step of cholesterol biosynthesis. We report here the synthesis and in vivo activity of a series of squalene synthase inhibitors that contain isosteric replacements for the farnesyl chain of the known inhibitor benzyl farnesyl amine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788383
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