Small peptide inhibitors of α4β7 mediated MAdCAM-1 adhesion to lymphocytes

Specificity of leukocyte trafficking to intestinal mucosal tissues is largely mediated by MAdCAM-1/α4β7 interaction. A series of small peptides was prepared to establish L-D-T-S-L as a recognition motif involved in the α4β7 interaction. N-Terminus acylation of the L-D-T-S-L motif has led to low micromolar inhibitors of leukocyte adhesion. Leukocyte trafficking to intestinal mucosal tissues is largely mediated by a MAdCAM-1/α4β7 interaction. A series of small peptides were prepared to establish L-D-T-S-L as a recognition motif involved. N-Terminus acylation of the L-D-T-S-L yielded micromolar inhibitors of leukocyte adhesion.