Author/Authors :
Alan P. Kozikowski، نويسنده , , Yi Liao، نويسنده , , Werner Tückmantel، نويسنده , , Shaomeng Wang، نويسنده , , Sergey Pshenichkin، نويسنده , , Alexander Surin، نويسنده , , Christian Thomsen، نويسنده , , Jarda T. Wroblewski، نويسنده ,
Abstract :
Chemical approaches to the (−)- and (+)-trans-2-carboxyazetidine-3-acetic acids (−)-1 and (+)-1, and their homologues (−)-2 and (+)-2, compounds that represent rigidified analogues of glutamate (glu), are reported together with the complete biological characterization of (+)-1 (t-CAA) at the known glu recognition sites. t-CAA was found to be an inhibitor of Na+-dependent glu uptake and to act as a kainate receptor ligand
