مرکز منطقه ای اطلاع رساني علوم و فناوري - (S)-4-amino-5-chloro-3-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (TRIZAC), a high-affinity ligand for the 5-HT-3 receptor

Title of article :

(S)-4-amino-5-chloro-3-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (TRIZAC), a high-affinity ligand for the 5-HT-3 receptor

Author/Authors :

Tomas de Paulis، نويسنده , , Bakula L. Trivedi، نويسنده , , Zhang-Jin Zhang، نويسنده , , Dennis E. Schmidt، نويسنده , , Michael H. Ebert، نويسنده , , William A. Hewlett، نويسنده ,

Issue Information :

روزنامه با شماره پیاپی سال 1996

Pages :

From page :

2657

To page :

2662

Abstract :

TRIZAC is one of the most potent 5-HT-3 receptor antagonist reported to date, having 20-fold higher affinity than (S)-5-todozacopride. This high affinity (K1 0.05 ± 0.01 nM) and a moderate apparent lipophilicity (log Papp 2.12) makes TRIZAC a promising ligand for studying 5-HT-3 receptors.

Journal title :

Bioorganic & Medicinal Chemistry Letters

Serial Year :

1996

Journal title :

Bioorganic & Medicinal Chemistry Letters

Record number :

788413

Link To Document :

https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=788413