Title of article
A simple synthesis of biaryl phospholipase A2 inhibitors: Probing hydrophobic effects
Author/Authors
Dane M. Springer، نويسنده , , Joanne J. Bronson، نويسنده , , Muzammil M. Mansuri، نويسنده , , David O. Nettleton، نويسنده , , Kenneth M. Tramposch، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2669
To page
2672
Abstract
A series of biaryl acids has been synthesized by treating diphenic anhydride with a variety of amines. The one step strategy allows the rapid interchange of groups for evaluating the hydrophobic constraints of inhibitors of phopholipase A2. The most active inhibitor synthesized displayed an IC50 = 6 μM against human platelet phospholipase A2.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788415
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