Title of article
Conversion of the phytoestrogen coumestrol into a selective estrogen receptor modulator (SERM) by attachment of an amine-containing sidechain
Author/Authors
Timothy A. Grese، نويسنده , , Harlan W. Cole، نويسنده , , David E. Magee، نويسنده , , D. Lynn Phillips، نويسنده , , Pam K. Shetler، نويسنده , , Lorri L. Short، نويسنده , , Andrews L. Glasebrook، نويسنده , , Henry U. Bryant، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2683
To page
2686
Abstract
The naturally occurring estrogen mimetic coumestrol has been shown to stimulate proliferation of MCF-7 mammary tumor cells and to cause uterotrophic effects in ovariectomized (OVX) rats. Attachment of a basic amine-containing sidechain to C-6 of coumestrol converts this estrogen agonist into an antagonist in breast and uterine tissue, while maintaining its estrogen-like activity as a hypocholesterolemic agent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788418
Link To Document