Author/Authors :
Akira Yamada، نويسنده , , Kouji Hattori، نويسنده , , Satoru Kuroda، نويسنده , , Toshiyuki Chiba، نويسنده , , Toshiaki Kamimura، نويسنده , , Kazuo Sakane، نويسنده ,
Abstract :
The synthesis antibacterial activity and DHP-susceptibility of a series of novel 2-vinyl carbapenems is described. Carbapenems having a 1′-substituted vinyl moiety at the 2 position were found to be very stable toward DHP-1, displaying comparable stability to compounds with a 1β-methyl functionality.
