Title of article
Synthesis and biological activities of [N-MeLeu5] didemnin B
Author/Authors
Amy J. Pfizenmayer، نويسنده , , Joshi Ramanjulu، نويسنده , , Matthew D. Vera، نويسنده , , Xiaobin Ding، نويسنده , , Dong Xiao، نويسنده , , Wei-Chuan Chen، نويسنده , , Madeleine M. Joullié، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2713
To page
2716
Abstract
Based on information from X-ray, NMR, and SAR data, the N,O-diMeTyr5 unit of didemnim B was believed to interact with receptors. To ascertain the importance of this unit, an analog was synthesized in which the N,O-diMeTyr5 moiety was replaced with N-McLeu. Preliminary biological testing showed that the analog retained antitumor activity and the ability to inhibit protein biosynthesis.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788424
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