Title of article
Synthesis and in vivo antimatarial activity of 12α-trifluoromethyl-hydroartemisinin
Author/Authors
Ahmed Abouabdellah، نويسنده , , Jean-Pierre Bégué، نويسنده , , Daniele Bonnet-Delpon، نويسنده , , Jean-Charles Gantier، نويسنده , , Truong Thi Thanh Nga، نويسنده , , Truong Dinh Thac، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2717
To page
2720
Abstract
12α-Trifluoromethyl-hydroartemisinin 4 was selectively prepared from the reaction of artemisinin 1 with TMSCF3 in good yields. The α configuration of the CF3 substituent was established by NMR experiments. Compound 4 exhibits a better antimalarial activity against Plasmodium vinckei in mice, than artemisinin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788425
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