Author/Authors :
Naoyuki Nishikawa، نويسنده , , Hiroyuki Komazawa، نويسنده , , Atsushi Orikasa، نويسنده , , Mitsuo Yoshikane، نويسنده , , Jiro Yamaguchi، نويسنده , , Masayoshi Kojima، نويسنده , , Mitsunori Ono، نويسنده , , Isamu Itoh، نويسنده , , Ichiro Azuma، نويسنده , , Hideki Fujii، نويسنده , , Jun Murata، نويسنده , , Ikuo Saiki، نويسنده ,
Abstract :
Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects of experimental lung metastasis of murine melanoma and adenosine 5′-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient theraputic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation
