Author/Authors :
Doreen M. Ashworth، نويسنده , , Butrus Atrash، نويسنده , , Graham R. Baker، نويسنده , , Andrew J. Baxter، نويسنده , , Paul D. Jenkins، نويسنده , , D. Michael Jones، نويسنده , , Michael Szelke، نويسنده ,
Abstract :
A series of stable, very potent inhibitors of dipeptidyl peptidase IV has been developed. A number of dipeptide analogues, incorporating a 4-cyanothiazolidide, were found to have Ki values of less than 1 nM versus human DP-IV and half-lives of between 5 and 27h in aqueous solution (pH 7.4).
