Title of article
A small library of peptidomimetics to systematically vary and test the effects of X1 constraints
Author/Authors
Kevin Burgess، نويسنده , , Claude Godbout، نويسنده , , Li Wen، نويسنده , , Kemal Payza، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
2761
To page
2764
Abstract
A library of 47 peptidomimetics of YGGFLRFa was prepared wherein 32 of these contained 2,3-methanoleucine. This library was tested for binding the neuropeptide FF receptor where neuropeptide FF is FLFQPQRFa, an anti-opiate peptide. This study illustrates how conformational constraints can be systematically varied in a library forward to determine the best conformational restrictions for the desired activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788435
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