Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors
Author/Authors :
Stephen R. Bertenshaw، نويسنده , , John J. Talley، نويسنده , , D.J. Rogier، نويسنده , , Matthew J. Graneto، نويسنده , , Carol M. Koboldt، نويسنده , , Yan Zhang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Pages :
4
From page :
2827
To page :
2830
Abstract :
Benzothiopyranopyrazoles and benzopyranopyrazoles containing either a sulfone or sulfonamide moiety were synthesized and tested for COX-1 and COX-2 inhibition. This new class of COX-2 selective inhibitors possess antiinflammatory activity in vivo.
