Author/Authors :
Kuo-Long Yu، نويسنده , , Jacek Ostrowski، نويسنده , , Simon Chen، نويسنده , , Kenneth M. Tramposch، نويسنده , , Peter R. Reczek، نويسنده , , Muzammil M. Mansuri، نويسنده , , John E. Starrett Jr.، نويسنده ,
Abstract :
The keto linker of 2-naphthoate retinoid 1 has been found nonessential for RAR transactivation activity and can be replaced with heteroatoms such as S, O, N without significant reduction of the activity. On the other hand, substitutions on the aromatic rings of retinoids 1 and 2 resulted in analogs with reduced potentcy and RAR selectivity.
