Title of article
1-(Dihydroxyphosphynyl)vinyl phosphate: The phosphonate analogue of phosphoenolpyruvate is a pH-dependent substrate of Kdo8P synthase
Author/Authors
Yaakov Benenson، نويسنده , , Valery Belakhov، نويسنده , , Timor Baasov، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
2901
To page
2906
Abstract
The phosphonate analogue of PEP (structure 5), in which the carboxylate group is replaced by an isosteric phosphonate, was synthesized and evaluated as a substrate and as an inhibitor of the Kdo8P synthase. It was demonstrated that 5 is a very slow, pH-dependent substrate of the enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788463
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