Synthesis and evaluation of novel 1,5-Benzodiazepines as potent and selective CCK-B ligands. Effect of the substitution of the N-5 phenyl with alkyl groups

Synthesis and evaluation of novel 1,5-Benzodiazepines as potent and selective CCK-B ligands. Effect of the substitution of the N-5 phenyl with alkyl groups Original Research Article Pages 2957-2962 Gabriella Finizia, Daniele Donati, Beatrice Oliosi, Maria Elvira Tranquillini, Antonella Ursini Close Close preview | Purchase PDF (247 K) | Related articles | Related reference work articles AbstractAbstract | ReferencesReferences Abstract The synthesis and biological evaluation of both 3-ureido and 3-carbamate derivatives of 1,5-benzodiazepines bearing bulky alkyl substituents at N-1 and N-5 positions is reported. Their activity as CCK-B receptor antagonists is discussed and compared with the related N-5-phenyl derivatives. Article Outline • References