Title of article
Novel tricyclic aminoacetyl and sulfonamide inhibitors of Ras farnesyl protein transferase
Author/Authors
F. George Njoroge، نويسنده , , Bancha Vibulbhan، نويسنده , , Carmen S. Alvarez، نويسنده , , W. Robert Bishop، نويسنده , , Joanne Petrin، نويسنده , , Ronald J. Doll، نويسنده , , V. Girijavallabhan، نويسنده , , Ashit K. Ganguly، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
2977
To page
2982
Abstract
Novel tricyclic FPT inhibitors with submicromolar FPT activity are described. Greatly enhanced FPT activity is realized with phthaloyl derivatized amino compound 2k, which showed FPT inhibitory activity of IC50 = 0.66 μM. Sulfonamides 5g and 50 were also found to be potent FPT inhibitor. SAR resulting from a variety of tricyclic amino acids and sulfonamide derivatives is discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788480
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