Author/Authors :
Joaquin Campos Rosa، نويسنده , , Bridgitte M. Beckwith-Hall، نويسنده , , Dimitrios Galanakis، نويسنده , , C. Robin Ganellin، نويسنده , , Philip M. Dunn، نويسنده , , Donald H. Jenkinson، نويسنده ,
Abstract :
Based on the structure-activity analysis of two series of blockers of the small conductance Ca2+-activated K+ (SKCa) channel, a novel class of bis-quinolinium cyclophane blockers has been designed and synthesised. These compounds exhibit submicromolar activity; UCL 1530 (4) is a useful agent since it has been shown (elsewhere) to be selective for the neuronal SKCa channel (IC50 = 80 nM) relative to hepatocyte channels.
