Title of article
α-((Tetronoyl)oxy)- and α-((tetramoyl)oxy)methyl ketone inhibitors of the interleukin-1β converting enzyme (ICE)
Author/Authors
Todd L. Graybill، نويسنده , , Catherine P. Prouty، نويسنده , , Gary J. Speier، نويسنده , , Denton Hoyer، نويسنده , , Roland E. Dolle، نويسنده , , Carla T. Helaszek، نويسنده , , Mark A. Ator، نويسنده , , Joanne Uhl، نويسنده , , Joost Strastes، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
41
To page
46
Abstract
Aryl-substituted tetronic acids, tetramic acids, and cyclic β-dicarbonyl moieties were evaluated as leaving groups in the peptidyl-COCH2-X type inhibitor iii. Tripeptidyl aspartyl α-((tetronoyl)oxy)- and α-((tetramoyl)oxy)methyl ketone derivatives demonstrate potent time-dependent inhibition (kobs/[I] 100,000–250,000 M−1s−1) of the cysteine protease ICE.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788505
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