Title of article
Synthesis and biological activity of novel 3′-trifluoromethyl taxoids
Author/Authors
Iwao Ojima، نويسنده , , John C. Slater، نويسنده , , Paula Pera، نويسنده , , Jean M. Veith، نويسنده , , Ahmed Abouabdellah، نويسنده , , Jean-Pierre Bégué، نويسنده , , Ralph J. Bernacki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
133
To page
138
Abstract
Second generation taxoids possessing a trifluoromethyl moiety in place of the 3′-phenyl group are synthesized by means of the β-LactamSynthonMethod. The in vitro cytotoxicities of these new taxoids are evaluated against several different human cancer cell lines and found to exhibit greatly enhanced activities as compared to those of paclitaxel and docetaxel. The activity enhancement is most remarkable against a drug-resistant breast cancer cell line, MCF7-R, expressing
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788525
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