Title of article
Synthesis and biological evaluation of 14-alkoxymorphinans. 14.1 14-ethoxy-5-methyl substituted indolomorphinans with δ opioid receptor selectivity
Author/Authors
Helmut Schmidhammer، نويسنده , , Dietmar Daurer، نويسنده , , Martina Wieser، نويسنده , , Krisztina Monory and، نويسنده , , Anna Borsodi، نويسنده , , Jackie Elliott and، نويسنده , , John R. Traynor، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
151
To page
156
Abstract
The 5-methyl and 14-ethoxy substituted analogues (compounds 2 – 4) of the δ opioid receptor antagonist naltrindole showed similar selectivity when compared with the reference drug. Compound 2 was a δ receptor antagonist in the mouse vas deferens preparation (MVD) exhibiting considerably higher selectivity ratios than naltrindole, while compound 4 was found to be a full and potent δ receptor agonist in the MVD.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788528
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