Title of article
Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibitor
Author/Authors
Lawrence L. Martin، نويسنده , , Larry Davis، نويسنده , , Joseph T. Klein، نويسنده , , Peter Nemoto، نويسنده , , Gordon E. Olsen، نويسنده , , Gina M. Bores، نويسنده , , Fernando Camacho، نويسنده , , Wayne W. Petko، نويسنده , , Douglas K. Rush، نويسنده , , David Selk، نويسنده , , Craig P. Smith، نويسنده , , Hugo M. Vargas، نويسنده , , James T. Winslow، نويسنده , , Richard C. Effland، نويسنده , , David M. Fink، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
157
To page
162
Abstract
A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents with enhanced cholinomimetic properties for the treatment of Alzheimerʹs disease. Compound 5a (P10358, 1-[3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate) emerged as a potent, reversible acetylcholinesterase inhibitor that significantly enhanced performance on oral or parenteral administration in learning and memory paradigms.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788529
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