Author/Authors :
Seiichiro Tabuchi، نويسنده , , Harunobu Ito، نويسنده , , Hajime Sogabe، نويسنده , , Masako Kuno، نويسنده , , Ikuyo Katsumi، نويسنده , , Naoko Yamamoto، نويسنده , , Hitoshi Mitsui، نويسنده , , Yoshinari Satoh، نويسنده ,
Abstract :
A novel series of potent CCK-A and CCK-B dual antagonists has been prepared which incorporate a methyl substituent at the 9 position of a 1,4-benzodiazepine ring system. FR193108 ((+)-11) was selected for further biological evaluation, and is expected to be more efficacious than CCK-A selective antagonists for the treatment of pancreatitis, since it has high and well-balanced affinities for both CCK-A and -B receptors.
