Title of article :
Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs
Author/Authors :
Kiyotake Suenaga، نويسنده , , Noriyuki Kamei، نويسنده , , Youko Okugawa، نويسنده , , Masaki Takagi، نويسنده , , Atsushi Akao، نويسنده , , Hideo Kigoshi، نويسنده , , Kiyoyuki Yamada، نويسنده ,
Abstract :
The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.
