Author/Authors :
Dieter Dorsch، نويسنده , , Werner W. K. R. Mederski، نويسنده , , Mathias Osswald، نويسنده , , Ralf M. Devant، نويسنده , , Claus-Jochen Schmitges، نويسنده , , Maria Christadler، نويسنده , , Claudia Wilm، نويسنده ,
Abstract :
Highly active endothelin receptor antagonists can be obtained by replacing the aryloxy group of L-749,329 by diversely substituted pyridazinone residues. The syntheses and structure-activity relationships of the new aryl-oxopyridazinyl-N-(4-arylsulfonyl)-acetamides 2 are reported. 2p with a simple dimethyl-pyridazinone moiety was one of the most potent compounds in vitro.
