Author/Authors :
Izzy Boyfield، نويسنده , , Martyn C. Coldwell، نويسنده , , Michael S. Hadley، نويسنده , , Maureen A. M. Healy، نويسنده , , Christopher N. Johnson، نويسنده , , David J. Nash، نويسنده , , Graham J. Riley، نويسنده , , Emma E. Scott، نويسنده , , Stephen A. Smith، نويسنده , , Geoffrey Stemp، نويسنده ,
Abstract :
A series of 2,5-disubstituted-1H-pyrroles (4 – 26) has been prepared where the conformational requirements of the N-ethyl, N-benzyl side-chain of 1 and the effect of introducing substituents into the benzyl group have been investigated. The (R)-α-methylbenzyl 6 and aminoindane 10 side-chains retained high affinity for the dopamine D3 receptor, although neither showed the selectivity of 2-phenylazacycloheptane 2.
