Title of article
Studies on the active conformation of the NK1 antagonist CGP 49823. Part 21. Fluoro-olefin analogs of tertiary amide rotamers.
Author/Authors
Siem J. Veenstra، نويسنده , , Kathleen Hauser، نويسنده , , Peter Felber، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
351
To page
354
Abstract
Four fluoro-olefin analogs of CGP 49823 have been synthesized. Comparison of their binding affinities for the NK1 receptor suggests an active conformation of CGP 49823, where the aromatic ring of the benzamide has a syn orientation towards the 2-benzyl substituent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788567
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