New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases

New N-alkyl, alkenyl and benzyl substituted DNJ derivatives incorporating a silicon atom in the substituent were synthesised. Kinetic parameters (Ki, t1/2) for inhibition of rat intestinal α-glucohydrolases as well as human lysosomal α-glucosidases were measured. New DNJ derivatives are potent and selective inhibitors of intestinal α-glucohydrolases.