Title of article
Replacements for lysine in -seryl- -lysyl dipeptide amide inhibitors of candida albicans myristoyl-CoA:protein N-myristoyltransferase
Author/Authors
David L. Brown، نويسنده , , Balekudru Devadas، نويسنده , , Hwang-Fun Lu، نويسنده , , Srinivasan Nagarajan، نويسنده , , Mark E. Zupec، نويسنده , , Sandra K. Freeman، نويسنده , , Charles A. McWherter، نويسنده , , Daniel P. Getman، نويسنده , , James A. Sikorski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
379
To page
382
Abstract
A survey of potential cyclic and acyclic lysine replacements in known -seryl- -lysyl dipeptide inhibitors of C. albicans NMT identified the thioether 16 and glycinamide 18 as submicromolar inhibitors of C. albicans NMT, which retained good selectivity over the human enzyme. All of the heterocyclic lysine mimetics that were examined exhibited dramatically weaker affinity with the fungal enzyme
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788573
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