Title of article
Peptide based inhibitors of interleukin-8: structural simplification and enhanced potency
Author/Authors
Michael R. Attwood، نويسنده , , Elizabeth A. Conway، نويسنده , , Rachel M. Dunsdon، نويسنده , , John R. Greening، نويسنده , , Balraj K. Handa، نويسنده , , Philip S. Jones، نويسنده , , Steven C. Jordan، نويسنده , , Elizabeth Keech، نويسنده , , Francis X. Wilson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
429
To page
432
Abstract
Important areas of a lead peptide inhibitor of IL-8 had been previously identified. Chemical modification led to the identification of key amide bonds which allowed the replacement of the central section of the peptide with modified amino acids and spacers. This approach led to inhibitors of lower molecular weight and of increased potency.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788584
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