Digitalis-like compounds: Synthesis and biological evaluation of 3β-(aminoalkylthio) derivatives

The synthesis and the binding affinities to the digitalis receptor on the Na+,K+-ATPase of a series of 3β-(aminoalkylthio) digitalis derivatives are described. In most cases these derivatives showed a higher binding affinity than that of the corresponding 3β-hydroxy and 3β-mercapto parent compoubds.