Title of article
Effects of CpG methylation to double stranded DNA breaks by Cu(II)-podophyllotoxin derivative complexes
Author/Authors
Riichi Tawa، نويسنده , , Masashi Takami، نويسنده , , Yasuhiro Imakura، نويسنده , , Kuo-Hsiung Lee، نويسنده , , Hiromu Sakurai ، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
489
To page
494
Abstract
Site-specific double stranded DNA breaks by •OH radicals generated from podophyllotoxin related compounds in the presence of Cu(II) ion were investigated and the neighboring effects of 5-methylcytosine on double stranded DNA cleavage, especially on methylated CpG sites, were evaluated.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788596
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