Conversion of acyclic nonpeptide CCK antagonists into CCK agonists

The CCK antagonists RP 69758 and (R)-lorglumide were converted into CCK agonists by the introduction of an N-isopropylanilide agonist “trigger.” The common structural features of these ligands suggest that nonpeptide agonists and antagonists bind to a common site in the CCK receptor.