Title of article
Synthesis and structural optimization of 7-(3,3-disubstituted-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acids as antibacterial agents
Author/Authors
Hiroyuki Kitani، نويسنده , , Tsuyoshi Kuroda، نويسنده , , Akihiko Moriguchi، نويسنده , , Hideki Ao، نويسنده , , Fumihiro Hirayama، نويسنده , , Yoshifumi Ikeda، نويسنده , , Takeshi Kawakita، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
515
To page
520
Abstract
A series of the titled compounds were synthesized and tested for antibacterial activities in comparison with typical fluoroquinolones. (S)-3-Aminomethyl-3-fluoromethyl derivative (Y-688) was confirmed to be optimal because of being most active especially against Gram-positive bacteria including fluoroquinolone-resistant strains and showing high photostability.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788601
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