Title of article
Design, synthesis, and evaluation of orally active fibrinogen inhibitors
Author/Authors
Akito Tanaka، نويسنده , , Hiroyoshi Sakai، نويسنده , , Takatoshi Ishikawa، نويسنده , , Toshiaki Aoki، نويسنده , , Yukio Motoyama، نويسنده , , Hisashi Takasugi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
521
To page
526
Abstract
Low molecular weight and orally active fibrinogen inhibitors are described. The compounds studied in this work were rationally designed based on a metabolic study of a peptidic fibrinogen inhibitor, 4-(4-amidinophenoxy)butanoylaspartylvaline (1, FK633), which led to the synthesis of a potent and orally active antiplatelet agent, 4-(4-amidinophenoxy)butanoylaspartylvalylthiomorpholine 1,1-dioxide (3f, FR158999).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788602
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