Title of article
A practical and scalable synthesis of SR 142801, a tachykinin NK3 antagonist
Author/Authors
Huai. G. Chen، نويسنده , , F. -Z. Chung، نويسنده , , O. P. Goel، نويسنده , , D. Johnson، نويسنده , , S. Kesten، نويسنده , , J. Knobelsdorf، نويسنده , , H. T. Lee، نويسنده , , J. R. Rubin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
555
To page
560
Abstract
A practical and scalable total synthesis of tachykinin NK3 receptor antagonist SR 142801, (R)-N-[1-[3-[1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-4-piperidinyl]-N-methyl acetamide 1 is described. The absolute configuration of the key intermediate 7 was determined by single crystal X-ray crystallography, on the basis of which, the absolute configuration of SR 142801 should be (R)-(+), instead of the recently reported (S)-(+).1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788608
Link To Document