Title of article
Synthesis of new maleimide derivatives of daunorubicin and biological activity of acid labile transferrin conjugates
Author/Authors
Felix Kratz، نويسنده , , Ulrich Beyer، نويسنده , , Peter Schumacher، نويسنده , , Michael Kruger، نويسنده , , Heike Zahn، نويسنده , , Thomas Roth، نويسنده , , Heinz H. Fiebig، نويسنده , , Clemens Unger، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
617
To page
622
Abstract
Maleimide groups were bound to the 3′-amino position of daunorubicin through a benzamide bond or to the 13-keto position through a benzoyl hydrazone or phenylacetyl hydrazone bond. The acid labile transferrin conjugates prepared with the latter two derivatives exhibited high activity in human melanoma cells (MEXF 989) using a clonogenic cell assay comparable to or exceeding that of daunorubicin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788620
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