Title of article
The synthesis and activity of spiroindane growth hormone secretagogues
Author/Authors
James R. Tata، نويسنده , , Ravi P. Nargund، نويسنده , , Marcia M. Murphy، نويسنده , , David B. R. Johnston، نويسنده , , Arthur A. Patchett، نويسنده , , Kang Cheng، نويسنده , , Liente Wei، نويسنده , , Wanda W. -S. Chan، نويسنده , , Bridget Butler، نويسنده , , Thomas M. Jacks، نويسنده , , Gerard Hickey، نويسنده , , Roy Smith، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
663
To page
668
Abstract
The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788629
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