Title of article :
Design, synthesis and biological evaluation of 1,3-diaminopropanes: a new class of polyamine analogs as leishmanicidal agents
Author/Authors :
Versha Vinay Kumar، نويسنده , , Sudhir K. Singh، نويسنده , , (Late) S. Sharma، نويسنده , , A. P. Bhaduri، نويسنده , , Suman Gupta، نويسنده , , Alima Zaidi، نويسنده , , Suman Tiwari، نويسنده , , J. C. Katiyar، نويسنده ,
Abstract :
Analogs of 1,3-diaminopropane as inhibitors for the growth of have been synthesized and evaluated for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4-methylpiperidine piperazine (4ef) exhibited significant inhibitory efficacy against by oral and intraperitoneal route of administration.
