Author/Authors :
Tetsutaro Kimachi، نويسنده , , Ken-ichi Sugita، نويسنده , , Yoshinori Tamura، نويسنده , , Miyuki Kagawa، نويسنده , , Kumi Yamasaki، نويسنده , , Fumio Yoneda، نويسنده , , Takuma Sasaki، نويسنده ,
Abstract :
A series of 5-deazaflavo-10,11-quinones having o-quinone structure in the molecule were synthesized. The cytotoxicity of 5-deazaflavo-6,9-quinones (p-quinone derivatives) and 5-deazaflavo-10,11-quinones (o-quinones) was evaluated in vitro against L1210 and KB cells. Some of the synthesized compounds exhibited cytotoxic activity comparable to that of mytomycin C.
