Author/Authors :
Yi Li، نويسنده , , John E. Starrett، نويسنده , , Nicholas A. Meanwell، نويسنده , , Graham Johnson، نويسنده , , William E. Harte، نويسنده , , Steven I. Dworetzky، نويسنده , , Christopher G. Boissard، نويسنده , , Valentin K. Gribkoff، نويسنده ,
Abstract :
Three-dimensional database searching based on the pharmacophore model of the known maxi-K opener NS-004 (1) and electrophysiological evaluation led to the discovery of flavonoids (3c and 3d) as openers of the cloned maxi-K channel mSlo expressed in Xenopus laevis oocytes. The cyclic constrained flavonoids were found to be more efficacious than the acyclic phloretin.
