Title of article
Rational design of selective thrombin inhibitors
Author/Authors
Sangsoo Kim، نويسنده , , Sang Yeul Hwang، نويسنده , , Young Kwan Kim، نويسنده , , Mikyung Yun، نويسنده , , Yeong Soo Oh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
769
To page
774
Abstract
Thrombin inhibitors with functionalized benzamidines as surrogates for arginine were designed, synthesized, and characterized. Amino acid sequence difference in the position 190 between thrombin and trypsin was exploited in the design to enhance selectivity over trypsin. A representative compound 6 showed high potency (Ki of 45.5 nM) and extremely high specificity over trypsin (over 10,000 fold).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788650
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